Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology

Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology

Most cells in mammalian tissues usually contain a diploid complement of chromosomes. However, numerous studies have demonstrated a major role of "diploid-polyploid conversion" during physiopathological processes in several tissues. In the liver parenchyma, progressive polyploidization of hepatocytes takes place during postnatal growth. Indeed, at the suckling-weaning transition, cytokinesis fai...

Cannabinoids Receptors in Liver: Diet and Physiopathology

Cannabis Sativa has been used for its psychoactive and medicinal properties for millennia. However, knowledge into its mechanism of action has only emerged the last decades. It was first demonstrated that brain had specific binding sites for ∆9-tetrahidrocannabinol (∆9-THC; the psychoactive compound of cannabis) named type 1-cannabinoid receptors (CB1R) and then cloned [1,2]. Discovery of CB1R,...

Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes.

Cyclin D1 is widely believed to regulate progression through G1 phase of the cell cycle, and previous studies have shown that this protein is induced during hepatocyte proliferation in culture and in vivo. In this study, the role of cyclin D1 in the cell cycle of primary rat hepatocytes was further examined. Following epidermal growth factor stimulation, cyclin D1 was upregulated at time points...

Physiopathology of parotid cell energetics

Attention was recently drawn to the production of Dglucose by salivary glands and its concentration in the saliva of both normal and diabetic subjects. Likewise, the identity and expression of selected transporters involved in the handling of the hexose by salivary glands were recently investigated in both normal and diabetic rats. In consideration of this information, the present report aims a...

Chlamydia, Hepatocytes and Liver